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Chlorination of the polluted water may produce odoriferous and objectionable-tasting chloropherols which are hazardous to health. These studies were undertaken to investigate the hazardous effects of cblorophenols to the rat. 1. The chlorophenols such as o-chlorophenol and 2,6-dichlorophenol inhibited rat growth and caused increment of the ratio between liver weight and body weight. 2. The hemoglobin content, hematocrit ratio and A/G of rat blood were decreased by chlorophenols administration. The activities of alkaline phosphatase, lactic dehydrogenase (LDH) and glutamate oxaloacetate transaminase (GOT) in serum as well as in liver were increased provisionally and decreased after one or two weeks administration. 3. The liver mitochondrial respiration (QO2) was inhibited by chlorophenols treatment in in-vivo and in-vitro test. 4. The liver microsomal cytochrome P-450 was decreased by chlorophenols administration. 5. Liver tissue was degenerated with congestion, atrophy, swelling, vacuolation, dilation of rough endoplasmic reticulum and denature of mitochondrial particle with swelling, and cristal destruction by chlorophenols administration. 6. After one and two weeks of administration of chlorophenols to Tat, the aberrations of bone marrow chromosome and inhibition of ifs mitosis were observed respectively.
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